Disruption of the Apelin-APJ System Worsens Hypoxia-Induced Pulmonary Hypertension
نویسندگان
چکیده
منابع مشابه
Disruption of the apelin-APJ system worsens hypoxia-induced pulmonary hypertension.
OBJECTIVE The G-protein-coupled receptor APJ and its ligand apelin are highly expressed in the pulmonary vasculature, but their function in this vascular bed is unclear. We hypothesized that disruption of apelin signaling would lead to worsening of the vascular remodeling associated with pulmonary hypertension (PH). METHODS AND RESULTS We found that apelin-null mice developed more severe PH c...
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ژورنال
عنوان ژورنال: Arteriosclerosis, Thrombosis, and Vascular Biology
سال: 2011
ISSN: 1079-5642,1524-4636
DOI: 10.1161/atvbaha.110.219980